abstract：BACKGROUND:Direct (non-vitamin-K-dependent) oral anticoagulants (DOAC) are given as an alternative to vitamin K antagonists (VKA) to prevent stroke and embolic disease in patients with atrial fibrillation that is not due to pathology of the heart valves. Fatal hemorrhage is rarer when DOACs are given (nonvalvular atria...

journal_title：Deutsches Arzteblatt international

authors： Maegele M,Grottke O,Schöchl H,Sakowitz OA,Spannagl M,Koscielny J

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Optimizing the emergency medical care chain might shorten the time to treatment of patients with ST-elevation myocardial infarction (STEMI). The initial care by a physician, and, in particular, correct ECG interpretation, are critically important factors. METHODS:From 1999 onward, data on the care of patien...

journal_title：Deutsches Arzteblatt international

authors： Stockburger M,Maier B,Fröhlich G,Rutsch W,Behrens S,Schoeller R,Theres H,Poloczek S,Plock G,Schühlen H

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Nail disorders can arise at any age. About half of all nail disorders are of infectious origin, 15% are due to inflammatory or metabolic conditions, and 5% are due to malignancies and pigment disturbances. The differential diagnosis of nail disorders is often an area of uncertainty. METHODS:This review is b...

journal_title：Deutsches Arzteblatt international

authors： Wollina U,Nenoff P,Haroske G,Haenssle HA

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:In view of the rise in antibiotic resistance and Clostridium difficile superinfection, close monitoring of antibiotic prescribing practices is essential so that targeted quality assurance measures can be taken. METHODS:We analyzed nationwide data from multiple statutory health insurance carriers on prescrip...

journal_title：Deutsches Arzteblatt international

authors： Bätzing-Feigenbaum J,Schulz M,Schulz M,Hering R,Kern WV

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Proper infant nutrition promotes healthy growth and development and lowers the risk of disease in later life. METHODS:This review is based on pertinent articles retrieved by a selective search, including guidelines, meta-analyses, and systematic reviews. RESULTS:Infants should be exclusively breast-fed unt...

journal_title：Deutsches Arzteblatt international

authors： Prell C,Koletzko B

更新日期：2016-06-24 00:00:00

abstract：BACKGROUND:Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking. METHODS:Nationwide case-related hospital DRG statistics for the years 2007-2013 were used t...

journal_title：Deutsches Arzteblatt international

authors： Fleischmann C,Thomas-Rueddel DO,Hartmann M,Hartog CS,Welte T,Heublein S,Dennler U,Reinhart K

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases are common in Europe, with prevalences as high as 1 in 198 persons (ulcerative colitis) and 1 in 310 persons (Crohn's disease). METHODS:This review is based on pertinent articles retrieved by a search in PubMed and in German and European guidelines and Cochrane reviews of control...

journal_title：Deutsches Arzteblatt international

authors： Wehkamp J,Götz M,Herrlinger K,Steurer W,Stange EF

更新日期：2016-02-05 00:00:00

abstract：BACKGROUND:Atraumatic necrosis of the femoral head is a common cause of hip arthrosis in middle age. In Germany, it affects 5000-7000 patients per year, corresponding to an incidence of 0.01%. Though rarer than primary hip arthrosis, it is still of major clinical and socio-economic significance. Patients with this prob...

journal_title：Deutsches Arzteblatt international

authors： Arbab D,König DP

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Atrial fibrillation is the most common type of cardiac arrhythmia and is associated with elevated rates of stroke, heart failure, hospital admission, and death. Its prevalence in the overall population is 1.5% to 2%. To convert atrial fibrillation to sinus rhythm, cardioversion is needed. METHODS:This revie...

journal_title：Deutsches Arzteblatt international

authors： Klein HH,Trappe HJ

更新日期：2015-12-11 00:00:00

abstract：BACKGROUND:The introduction of neurological stroke units and of thrombolysis with the intravenous (IV) administration of recombinant tissue-type plasminogen activator (tPA) have markedly improved the treatment of stroke. Five randomized trials of catheter-based interventional treatment of stroke with special stents wer...

journal_title：Deutsches Arzteblatt international

authors： Fiehler J,Gerloff C

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Abdominal and thoracic aortic aneurysms are diagnosed in 40 and 10 to 15 out of 100 000 persons per year, respectively. Fenestrated (fEVAR) and branched (bEVAR) stent grafts have been developed for abdominal juxtarenal and thoracoabdominal aneurysms. We discuss the patency and complication rates of fEVAR and...

journal_title：Deutsches Arzteblatt international

authors： Rylski B,Czerny M,Südkamp M,Russe M,Siep M,Beyersdorf F

更新日期：2015-11-27 00:00:00

abstract：BACKGROUND:Systematic reviews provide a structured summary of the results of trials that have been carried out on any particular subject. If the data from multiple trials are sufficiently homogenous, a meta-analysis can be performed to calculate pooled effect estimates. Traditional meta-analysis involves groups of tria...

journal_title：Deutsches Arzteblatt international

authors： Kiefer C,Sturtz S,Bender R

更新日期：2015-11-20 00:00:00

abstract：BACKGROUND:Most meniscus lesions are of non-traumatic origin. The indications for partial meniscectomy are controversial. METHODS:We systematically searched the literature for randomized controlled trials (RCTs) comparing partial meniscectomy with non-surgical treatment. RESULTS:Of 6870 articles retrieved by the lite...

journal_title：Deutsches Arzteblatt international

authors： Petersen W,Achtnich A,Lattermann C,Kopf S

更新日期：2015-10-16 00:00:00

abstract：BACKGROUND:Numerous studies from around the world have shown a positive association between case numbers and the quality of medical care. The evidence to date suggests that conformity to guidelines for the treatment of patients with breast cancer is better in German hospitals that have higher case numbers. METHODS:We ...

journal_title：Deutsches Arzteblatt international

authors： Köster C,Heller G,Wrede S,König T,Handstein S,Szecsenyi J

更新日期：2015-08-31 00:00:00

abstract：BACKGROUND:25% of all women report involuntary loss of urine, and 7% may require treatment. METHODS:This review is based on a selection of pertinent literature, including guidelines and Cochrane reviews. RESULTS:The assessment of pelvic floor dysfunction in women begins with a basic evaluation that is followed by spe...

journal_title：Deutsches Arzteblatt international

authors： Jundt K,Peschers U,Kentenich H

更新日期：2015-08-17 00:00:00

abstract：BACKGROUND:In Germany, rehabilitation is considered to be indicated after an acute hospital stay for the treatment of a severe cardiac condition. In comparative studies, at least 51% of German hospital patients with coronary heart disease (CHD) who were entitled to rehabilitative measures actually took part n rehabilit...

journal_title：Deutsches Arzteblatt international

authors： Schlitt A,Wischmann P,Wienke A,Hoepfner F,Noack F,Silber RE,Werdan K

更新日期：2015-08-03 00:00:00

abstract：BACKGROUND:About 17% of all children suffer from a mental disorder in early childhood, defined as the period up to the age of 6 years. METHODS:This review is based on publications retrieved by a selective search in PubMed and the Web of Science, as well as on the authors' clinical and scientific experience. RESULTS:I...

journal_title：Deutsches Arzteblatt international

authors： von Klitzing K,Döhnert M,Kroll M,Grube M

更新日期：2015-05-25 00:00:00

abstract：BACKGROUND:Hoarseness (dysphonia) is the reason for about 1% of all consultations in primary care. It has many causes, ranging from self-limited laryngitis to malignant tumors of the vocal cords. METHODS:This review is based on literature retrieved by a selective search in PubMed employing the terms "hoarseness," "hoa...

journal_title：Deutsches Arzteblatt international

authors： Reiter R,Hoffmann TK,Pickhard A,Brosch S

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Delirium is a common complication in elderly hospitalized patients. It prolongs the length of hospital stay, raises costs, increases the workload of the nursing staff, and may necessitate transfer of the patient to a nursing home. The risk of postoperative delirium is particularly high in elderly patients wi...

journal_title：Deutsches Arzteblatt international

authors： Kratz T,Heinrich M,Schlauß E,Diefenbacher A

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:The regional prevalence of risk factors can vary over time. The Study of Health in Pomerania (SHIP) addresses prevalence trends for common risk factors in a region in northeast Germany. METHODS:A longitudinal study was carried out from 1997 to 2001 (SHIP-0, with 4308 subjects), and a second, independent ran...

journal_title：Deutsches Arzteblatt international

authors： Völzke H,Ittermann T,Schmidt CO,Baumeister SE,Schipf S,Alte D,Biffar R,John U,Hoffmann W

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:International studies show that aggressive behavior against primary care physicians is not an uncommon occurrence. There has been no systematic study to date of the nature and frequency of such occurrences in Germany. METHODS:A four-page questionnaire was sent to a nationwide random sample of 1500 primary c...

journal_title：Deutsches Arzteblatt international

authors： Vorderwülbecke F,Feistle M,Mehring M,Schneider A,Linde K

更新日期：2015-03-06 00:00:00

abstract：BACKGROUND:Although the number of elderly patients with fractures is increasing, there have been only a few studies to date of the efficacy of collaborative treatment by trauma surgeons and geriatricians. METHODS:Data on patients over age 75 with femoral neck, trochanteric, proximal humeral, and pelvic ring fractures ...

journal_title：Deutsches Arzteblatt international

authors： Grund S,Roos M,Duchene W,Schuler M

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:The long-term use of opioid analgesic drugs to treat chronic non-cancer pain (CNCP) is a major component of pain pharmacotherapy. The interpretation of the evidence concerning its efficacy and risks is currently debated. METHODS:An interdisciplinary evidence- and consensus-based S3 guideline was updated on ...

journal_title：Deutsches Arzteblatt international

authors： Häuser W,Bock F,Engeser P,Tölle T,Willweber-Strumpfe A,Petzke F

更新日期：2014-10-24 00:00:00

abstract：BACKGROUND:The German Standing Committee on Vaccination (STIKO) recommends vaccination against human papillomaviruses (HPV) of the high-risk types 16 and 18. The duration of protection afforded by HPV vaccines has been reported in multiple studies to date but has not been systematically evaluated. METHOD:Systematic li...

journal_title：Deutsches Arzteblatt international

authors： Deleré Y,Wichmann O,Klug SJ,van der Sande M,Terhardt M,Zepp F,Harder T

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Familial hypercholesterolemia (FH) is a congenital disorder of lipid metabolism characterized by a marked elevation of the plasma concentration of LDL (low-density lipoprotein) cholesterol beginning in childhood and by the early onset of coronary heart disease. It is among the commonest genetic disorders, wi...

journal_title：Deutsches Arzteblatt international

authors： Klose G,Laufs U,März W,Windler E

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:One-third of all patients with epilepsy have persistent seizures despite medical treatment. If the origin of the seizures can be localized to a particular site in the brain, epilepsy surgery is a treatment option that addresses the cause of the problem. METHOD:The presurgical assessment and surgical treatme...

journal_title：Deutsches Arzteblatt international

authors： Schulze-Bonhage A,Zentner J

更新日期：2014-05-02 00:00:00

abstract：BACKGROUND:Acne is the most common skin disease in adolescence, with a prevalence of nearly 100%. About 60% of affected adolescents have mild acne for which they use non-prescription preparations without consulting a physician. The remaining 40% constitute the population of acne patients seen in medical practice. The c...

journal_title：Deutsches Arzteblatt international

authors： Gollnick HP,Zouboulis CC

更新日期：2014-04-25 00:00:00

abstract：BACKGROUND:Dear Doctor Letters (also known as Direct Healthcare Professional Communications) inform physicians about significant newly discovered drug risks and about measures to take to reduce these risks. How far these warnings actually influence prescribing behavior is unclear. METHOD:The Geriatrics in Bavaria-Data...

journal_title：Deutsches Arzteblatt international

authors： Schächtele S,Tümena T,Gaßmann KG,Fromm MF,Maas R

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is a common retinal disease in older people. In Europe, about 1.6% of persons over age 65 and more than 13% of persons over age 85 have late-stage AMD, which can severely impair vision. The development of AMD is influenced both by environmental factors and by a strong h...

journal_title：Deutsches Arzteblatt international

authors： Weber BH,Charbel Issa P,Pauly D,Herrmann P,Grassmann F,Holz FG

更新日期：2014-02-21 00:00:00

abstract：BACKGROUND:Lung transplantation is the final treatment option in the end stage of certain lung diseases, once all possible conservative treatments have been exhausted. Depending on the indication for which lung transplantation is performed, it can improve the patient's quality of life (e.g., in emphysema) and/ or prolo...

journal_title：Deutsches Arzteblatt international

authors： Hartert M,Senbaklavacin O,Gohrbandt B,Fischer BM,Buhl R,Vahld CF

更新日期：2014-02-14 00:00:00

abstract：BACKGROUND:Despite sparse documentation of their long-term therapeutic effects and side effects, antipsychotic drugs have come to be prescribed more frequently for children and adolescents in recent years, both in the USA and in Europe. No current data are available about antipsychotic prescriptions for this age group ...

journal_title：Deutsches Arzteblatt international

authors： Bachmann CJ,Lempp T,Glaeske G,Hoffmann F

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:The treatment of Hodgkin's disease (HD; also called Hodgkin's lymphoma) in children and adolescents with radiotherapy and chemotherapy leads to high survival rates but has a number of late effects. The most serious one is the development of a secondary malignant tumor, usually in the field that was irradiate...

journal_title：Deutsches Arzteblatt international

authors： Schellong G,Riepenhausen M,Ehlert K,Brämswig J,Dörffel W,German Working Group on the Long-Term Sequelae of Hodgkin's Disease.,Schmutzler RK,Rhiem K,Bick U,German Consortium for Hereditary Breast and Ovarian Cancer.

更新日期：2014-01-06 00:00:00

abstract：BACKGROUND:The German Standing Committee on Vaccination Recommendations (Ständige Impfkommission, STIKO) recommends standard vaccination against pneumococcal infections for all persons aged 60 or older, and for all persons of any age with an increased health risk. It is not known how many persons in the target group in...

journal_title：Deutsches Arzteblatt international

authors： Theidel U,Kuhlmann A,Braem A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Lung cancer is the leading cause of death from cancer in Germany. 90% of cases are due to the inhalation of tobacco smoke. About 40% of patients with newly diagnosed lung cancer are still smokers. A structured smoking cessation program is medically reasonable in this situation but is only rarely offered. ME...

journal_title：Deutsches Arzteblatt international

authors： Andreas S,Rittmeyer A,Hinterthaner M,Huber RM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The estimated prevalence of fetal alcohol syndrome (FAS) is 8 for every 1000 live births. FAS has serious, lifelong consequences for the affected children and their families. A variety of professionals deal with persons who have FAS, including pediatricians, general practitioners, neurologists, gynecologists...

journal_title：Deutsches Arzteblatt international

authors： Landgraf MN,Nothacker M,Kopp IB,Heinen F

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Pulsatile tinnitus, unlike idiopathic tinnitus, usually has a specific, identifiable cause. Nonetheless, uncertainty often arises in clinical practice about the findings to be sought and the strategy for work-up. METHODS:Selective literature review and evaluation of our own series of patients. RESULTS:Puls...

journal_title：Deutsches Arzteblatt international

authors： Hofmann E,Behr R,Neumann-Haefelin T,Schwager K

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:It is estimated that 1 million persons in Germany suffer from hepatic cirrhosis, which is the final stage of chronic inflammation of the liver. Cirrhosis has multiple causes, all of which lead to structural changes of the liver and to portal hypertension. The main complications of cirrhosis arise in turn: Th...

journal_title：Deutsches Arzteblatt international

authors： Sauerbruch T,Appenrodt B,Schmitz V,Spengler U

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is the end stage of chronic liver disease. Among the many liver disorders that can lead to cirrhosis, some progress rapidly (years) and others more slowly (decades). In Germany, cirrhosis is often a consequence of fatty liver disease due to alcoholism or other causes, but can also be c...

journal_title：Deutsches Arzteblatt international

authors： Wiegand J,Berg T

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infections are becoming more common, more severe, and more likely to recur. Conventional treatment with antibiotics often fails to eradicate the infection; even when it succeeds, recurrent infection is common. Complementary treatment with probiotic agents to reconstitute the physiologic...

journal_title：Deutsches Arzteblatt international

authors： Kleger A,Schnell J,Essig A,Wagner M,Bommer M,Seufferlein T,Härter G

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Pre-hospital hypotension in trauma patients is associated with high mortality. Especially for patients with severe traumatic brain injury (TBI), arterial normotension or even hypertension (AHT) is considered an important mechanism for sustaining adequate cerebral perfusion pressure. The effect of pre-hospita...

journal_title：Deutsches Arzteblatt international

authors： Sellmann T,Miersch D,Kienbaum P,Flohé S,Schneppendahl J,Lefering R,DGU Trauma Registry.

更新日期：2012-12-01 00:00:00